OncoBio Consolider Network

Understanding the Cancer Biology

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Ministerio de Economía y Competitividad


AMPK and PFKFB3 mediate glycolysis and survival in response to mitophagy during mitotic arrest
Elena Doménech, Carolina Maestre, Lorena Esteban-Martínez, David Partida, Rosa Pascual, Gonzalo Fernández-Miranda, Esther Seco, Ramón Campos-Olivas, Manuel Pérez, Diego Megias, Katherine Allen, Miguel López, Asish K. Saha, Guillermo Velasco, Eduardo Rial, Raúl Méndez, Patricia Boya, María Salazar-Roa & Marcos Malumbres.
Nature Cell Biology (2015). doi: 10.1038/ncb3231. August 31, 2015

An integrated portrait of the Chronic lymphocytic leukaemia genomic landscape by C. Lopez-Otin and co-workers.
This study identifies new recurrent driver mutations of the disease, and suggests clinical interventions that may improve the management of this neoplasia.

Puente XS, Beà S, Valdés-Mas R, Villamor N, Gutiérrez-Abril J, Martín-Subero JI, Munar M, Rubio-Pérez C, Jares P, Aymerich M, Baumann T, Beekman R, Belver L, Carrio A, Castellano G, Clot G, Colado E, Colomer D, Costa D, Delgado J, Enjuanes A, Estivill X, Ferrando AA, Gelpí JL, González B, González S, González M, Gut M, Hernández-Rivas JM, López-Guerra M, Martín-García D, Navarro A, Nicolás P, Orozco M, Payer ÁR, Pinyol M, Pisano DG, Puente DA, Queirós AC, Quesada V, Romeo-Casabona CM, Royo C, Royo R, Rozman M, Russiñol N, Salaverría I, Stamatopoulos K, Stunnenberg HG, Tamborero D, Terol MJ, Valencia A, López-Bigas N, Torrents D, Gut I, López-Guillermo A, López-Otín C, Campo E. Non-coding recurrent mutations in chronic lymphocytic leukaemia. Nature. 2015 Jul 22. doi: 10.1038/nature14666.

Ageing, reprogramming and therapeutic strategies for Néstor-Guillermo progeria syndrome and Hutchinson-Gilford progeria syndromes, by C. López-Otín et al.
Soria-Valles C, Osorio FG, Gutiérrez-Fernández A, De Los Angeles A, Bueno C, Menéndez P, Martín-Subero JI, Daley GQ, Freije JM, López-Otín C. NF-κB activation impairs somatic cell reprogramming in ageing. Nat Cell Biol. 2015 Jul 27. doi: 10.1038/ncb3207.

New treatments against obesity by M. Serrano et al.
Ortega-Molina A, Lopez-Guadamillas E, Mattison JA, Mitchell SJ, Muñoz-Martin M, Iglesias G, Gutierrez VM, Vaughan KL, Szarowicz MD, González-García I, López M, Cebrián D, Martinez S, Pastor J, de Cabo R, Serrano M. Pharmacological inhibition of PI3K reduces adiposity and metabolic syndrome in obese mice and rhesus monkeys. Cell Metab. 2015 Apr 7;21(4):558-70. doi: 10.1016/j.cmet.2015.02.017.

Reverting replicative stress and ageing by O. Fernández-Capetillo and cols.
Lopez-Contreras AJ, Specks J, Barlow JH, Ambrogio C, Desler C, Vikingsson S, Rodrigo-Perez S, Green H, Rasmussen LJ, Murga M, Nussenzweig A, Fernandez-Capetillo O. Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice. Genes Dev. 2015 Apr 1;29(7):690-5. doi: 10.1101/gad.256958.114.

Lysyl oxidases, Notch1 and skin cancer
Martin A, Salvador F, Moreno-Bueno G, Floristán A, Ruiz-Herguido C, Cuevas EP, Morales S, Santos V, Csiszar K, Dubus P, Haigh JJ, Bigas A, Portillo F, Cano A. Lysyl oxidase-like 2 represses Notch1 expression in the skin to promote squamous cell carcinoma progression. EMBO J. 2015 Apr 15;34(8):1090-109. doi: 10.15252/embj.201489975.

Notch in bladder cancer by M. Serrano, F.X. Real and cols.
Maraver A, Fernandez-Marcos PJ, Cash TP, Mendez-Pertuz M, Dueñas M, Maietta P, Martinelli P, Muñoz-Martin M, Martínez-Fernández M, Cañamero M, Roncador G, Martinez-Torrecuadrada JL, Grivas D, de la Pompa JL, Valencia A, Paramio JM, Real FX, Serrano M. NOTCH pathway inactivation promotes bladder cancer progression. J Clin Invest. 2015 Feb;125(2):824-30. doi: 10.1172/JCI78185.

New cellular mechanisms for the generation of platelet, by Malumbres et al.
Trakala M, Rodríguez-Acebes S, Maroto M, Symonds CE, Santamaría D, Ortega S, Barbacid M, Méndez J, Malumbres M. Functional reprogramming of polyploidization in megakaryocytes. Dev Cell. 2015 Jan 26;32(2):155-67. doi: 10.1016/j.devcel.2014.12.015.

About us

The OncoBIO Consolider Network was constituted in December 10th 2007 with the main goal of a better understand of the Cancer Biology.

This coordinated project will provide critical information for the development of new strategic opportunities aimed at improving those diagnostic and therapeutic approaches currently used to treat cancer patients.

Upcoming Events

19 October 2015

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If you are interested in working with us, send your CV indicating the position you want to apply to the e-mail oncobio@oncobio.org

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